主な受賞歴・業績

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●受賞
1989年　The 1989 Du Pont Pharmaceutical ACCP Young Investigator Award

●業績
［2009年］
（症例報告）

松井　祥子，杉山　英二，多喜　博文，河岸　由紀男，三輪　敏郎，林　龍二，丸山　宗治，戸邉　一之：ミクリッツ病と自己免疫性膵炎を合併し，IgG4陽性形質細胞浸潤を伴った細気管支炎の1例．日呼吸会誌 47: 139-144, 2009.

［2008年］
（原著・総説）

Hounoki H, Sugiyama E, Mohamed SG, Shinoda K, Taki H, Abdel-Aziz HO, Maruyama M, Kobayashi M, Miyahara T. Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression. Bone 42: 765-774, 2008.

篠田千恵，和田攻，丸山宗治：閉塞型睡眠時無呼吸症候群のCPAP治療継続のための要因の検討．日本呼吸ケア・リハビリテーション学会誌 18: 54-58, 2008.

丸山宗治：急性肺損傷/急性呼吸窮迫症候群（acute lung injury/acute respiratory distress syndrome; ALI/ARDS）．日本内科学会雑誌 97: 1358-1362, 2008.

（学会発表）

猪又峰彦，河岸由紀男，市川智巳，鈴木健介，山田　徹，三輪敏郎，今西信悟，林　龍二，松井祥子，丸山宗治，戸邉一之：成人気管支喘息におけるAsthma control testとQOL（SF-8）および臨床指標との関連について．第58回日本アレルギー学会秋季学術大会 2008.11. 東京.

丸山宗治，林龍二，河岸由紀男，山田徹，三輪敏郎，鈴木健介，市川智巳，松井祥子，戸辺一之：富山県内の一般医院での閉塞性肺疾患の疫学研究．第48回日本呼吸器学会学術講演会2008.6. 神戸．

山田徹，松島千紘，鈴木健介，市川智巳，河岸由紀男，三輪敏郎，林龍二，松井祥子，丸山宗治，戸辺一之：乳癌術後放射線照射を契機に発症したBOOPの3例．第48回日本呼吸器学会学術講演会 2008.6. 神戸．

（講演）

丸山宗治：慢性閉塞性肺疾患の診断と治療．白山ののいち医師会学術講演会 2008.4. 白山．

丸山宗治：富山県内の一般医院での慢性閉塞性肺疾患の疫学調査．COPD学術講演会 2008.6. 富山．

業績［2007年以前］

Fujishita T, Kishida M, Taki H, Shinoda C, Miyabayashi K, Fujishita M, Maruyama M, Mizushima Y, Kobayashi M. Detection of primary and metastatic lesions by [18F]fluoro-2-deoxy-D-glucose PET in a patient with thymic carcinoid. Respirology 12: 928-930, 2007.

Mohamed SG, Sugiyama E, Shinoda K, Taki H, Hounoki H, Abdel-Aziz HO, Maruyama M, Kobayashi M, Ogawa H, Miyahara T. Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells. Bone 41: 592-602, 2007.

Miyabayashi K, Maruyama M, Yamada T, Shinoda C, Hounoki K, Kanatani Y, Shinoda K, Kawagishi Y, Miwa T, Suzuki K, Arai N, Hayashi R, Matsui S, Sugiyama E, Kobayashi M. Isoproterenol suppresses cytokine-induced RANTES secretion in human lung epithelial cells through the inhibition of c-jun N-terminal kinase pathway. Biochem Biophys Res Commun 350: 753-761, 2006.

Ogawa H, Gomi T, Nishizawa M, Hayakawa Y, Endo S, Hayashi K, Ochiai H, Takusagawa F, Pitot HC, Mori H, Sakurai H, Koizumi K, Saiki I, Oda H, Fujishita T, Miwa T, Maruyama M, Kobayashi M. Enzymatic and biochemical properties of a novel human serine dehydratase isoform. Biochem Biophys Acta 64: 961-971, 2006.

Yamada T, Maruyama M, Fujita T, Miyabayashi K, Shinoda C, Kawagishi Y, Fujishita T, Hayashi R, Miwa T, Arai N, Matsui S, Sugiyama E, Kobayashi M. Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation. FEBS Lett 580: 4387-4391, 2006.

Shinoda C, Maruyama M, Fujishita T, Dohkan J, Oda H, Shinoda K, Yamada T, Miyabayashi K, Hayashi R, Kawagishi Y, Fujita T, Matsui S, Sugiyama E, Muraguchi A, Kobayashi M. Doxorubicin induces expression of multidrug resistance-associated protein 1 in human small cell lung cancer cell lines by the c-jun N-terminal kinase pathway. Int J Cancer 117: 21-31, 2005.

Kashii T, Gomi T, Oya T, Ishii Y, Oda H, Maruyama M, Kobayashi M, Masuda T, Yamazaki M, Nagata T, Tsukada K, Nakajima A, Tatsu K, Mori H, Takusagawa F, Ogawa H, Pitot HC. Some biochemical and histochemical properties of human liver serine dehydratase. Int J Biochem Cell Biol 37: 574-589, 2005.

Kamel Mohamed SG, Sugiyama E, Shinoda K, Hounoki H, Taki H, Maruyama M, Kobayashi M, Matsui K. Interleukin-4 inhibits RANKL-induced expression of NFATc1 and c-Fos: a possible mechanism for downregulation of osteoclastogenesis. Biochem Biophys Res Commun 329: 839-845, 2005.

Kawagishi Y, Yamaguchi T, Matsui S, Narukawa M, Fujita T, Oda H, Miwa T, Fujishita T, Arai N, Maruyama M, Kobayashi M. [A case of Pneumocystis pneumonia misidentified as methotrexate-induced pneumonitis] Nihon Kokyuki Gakkai Zasshi 43: 486-491, 2005.

Fujishita T, Narukawa M, Kawagishi Y, Fujita T, Maruyama M, Kobayashi M. [Steroid-refractory radiation pneumonitis treated with cyclosporin A] Nihon Kokyuki Gakkai Zasshi 43: 459-465, 2005.

Narukawa M, Maruyama M, Yasuoka A, Funada M, Kobayashi M. [Generalized tetanus with intractable autonomic cardiovascular instability in an aged woman] Kansenshogaku zasshi 79: 556-560, 2005.

Iwata M, Yamamoto Y, Fujita T, Hayashi R, Igarashi Y, Satou A, Sasaoka T, Maruyama M, Kobayashi M, Matsui K. [Ectopic ACTH-producing bronchial carcinoid tumor] Nippon Naika Gakkai Zasshi 93: 370-372, 2004.

Harada S, Sugiyama E, Takebe S, Taki H, Shinoda K, Mohamed SG, Maruyama M, Hamazaki T, Kobayashi M. Cooperative induction of 15-lipoxygenase in rheumatoid synovial cells by IL-4 and proinflammatory cytokines. Clin Exp Rheumatol 21: 753-758, 2003.

Shinoda K, Sugiyama E, Taki H, Harada S, Mino T, Maruyama M, Kobayashi M. Resting T cells negatively regulate osteoclast generation from peripheral blood monocytes. Bone 33: 711-720, 2003.

Hounoki H, Kawagishi Y, Oda H, Miwa T, Inomata M, Fujita T, Matsui S, Kashii T, Maruyama M, Kobayashi M. [Marked improvement of Lambert-Eaton myasthenic syndrome resulting from treatment for small cell lung carcinoma] Nihon Kokyuki Gakkai Zasshi 41: 331-335, 2003.

Fujita T, Maruyama M, Araya J, Sassa K, Kawagishi Y, Hayashi R, Matsui S, Kashii T, Yamashita N, Sugiyama E, Kobayashi M. Hydrogen peroxide induces upregulation of Fas in human airway epithelial cells via the activation of PARP-p53 pathway. Am J Respir Cell Mol Biol 27: 542-552, 2002.

Araya J, Maruyama M, Inoue A, Fujita T, Kawahara J, Sassa K, Hayashi R, Kawagishi Y, Yamashita N, Sugiyama E, Kobayashi M. Inhibition of proteasome activity is involved in cobalt-induced apoptosis of human alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 283: L849-L858, 2002.

Harada S, Sugiyama E, Taki H, Shinoda K, Fujita T, Maruyama M, Kobayashi M. D-penicillamine cooperates with copper sulfate to enhance the surface expression of functional Fas antigen in rheumatoid synovial fibroblasts via the generation of hydrogen peroxide. Clin Exp Rheumatol 20: 469-476, 2002.

Kawagishi Y, Mita H, Taniguchi M, Maruyama M, Oosaki R, Higashi N, Kashii T, Kobayashi M, Akiyama K. Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma. J Allergy Clin Immunol 109: 936-942, 2002.

Iwata M, Matsui S, Maruyama M, Taniguchi H, Oda H, Miwa T, Arai N, Yamashita N, Kobayashi M. [A case of acute respiratory failure associated with cholinergic crisis induced by distigmine bromide] Jap J Chest Dis 61: 84-91, 2002.

Araya J, Maruyama M, Sassa K, Fujita T, Hayashi R, Matsui S, Kashii T, Yamashita N, Sugiyama E, Kobayashi M. Ionizing radiation enhances matrix metalloproteinase-2 production in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 280: L30-L38, 2001.

Sugiyama E, Ikemoto M, Taki H, Maruyama M, Yamashita N, Kobayashi M. Mizoribine, an inhibitor of inosine monophosphate dehydrogenase, inhibits interleukin-5 production by freshly prepared rheumatoid synovial cells. Mod Rheumatol 11: 28-33, 2001.

Shinoda C, Hayashi R, Kawasaki A, Maruyama M, Kobayashi M. [A case of polymyositis complicated with pulmonry tuberculosis concerned with steroid resistance due to rifampin administration] Nihon Kokyuki Gakkai Zasshi 39: 955-960, 2001.

Miwa T, Maruyama M, Matsui S, Taniguchi H, Oda H, Arai N, Kasshii T, Yamashita N, Kobayashi M, Hara H, Izumi S, Takazakura E, Tsuji H, Minami M, Miyoshi S, Matsuda H. [A case of multiple emphysematous bullaed treated with living-donor lung transplantation from identical twin brothers] Nihon Kokyuki Gakkai Zasshi 39: 877-881, 2001.

Kawagishi Y, Oosaki R, Mita H, Maruyama M, Arai N, Taniguchi H, Kashii T, Yamashita N, Taniguchi M, Akiyama K, Kobayashi M. [Clinical significance of measurement of urinary leukotriene E4 in asthmatic patients without attack] Arerugi 50: 1096-1101, 2001.

Sugiyama E, Ozawa T, Taki H, Maruyama M, Yamashita N, Ohta M, Hirata M, Kobayashi M. Hereditary angioedema with a de nove mutation of exon 8 in the C1 inhibitor gene showing recurrent edema of the hands around the peripheral joints: importance for the differential diagnosis of joint swelling. Arthritis Rheum 44: 974-977, 2001.

Hayashi R, Yamashita N, Sugiyama E, Maruyama M, Matsui S, Yoshida Y, Arai N, Kobayashi M. [A case of primary Sjoegren’s syndrome with interstitial pneumonia showing bronchiolitis obliterans organizing pneumonia pattern and lymphofollicular formation] Nihon Kokyuki Gakkai Zasshi 38: 880-884, 2000.

Matsui S, Yamashita N, Maruyama M, Araya J, Oda H, Fujita T, Miwa T, Hayashi R, Arai N, Kashii T, Kobayashi M. [Acute eosinophilic pneumonia induced by cigarette smoking: positive lymphocyte stimulation test of a cigarette extract] Nihon Kokyuki Gakkai Zasshi 38: 807-811, 2000.

Hayashi R, Yamashita N, Matsui S, Fujita T, Araya J, Sassa K, Arai N, Yoshida Y, Kashii T, Maruyama M, Sugiyama E, Kobayashi M. Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms. Eur Respir J 16: 452-458, 2000.

Mao X, Kashii T, Sassa K, Fujishita T, Maruyama M, Kobayashi M, Liu S. Cloning of differentially expressed sequence tags from nickel-transformed human embryonic lung cells. Cancer Lett 161: 57-62, 2000.

Kawagishi Y, Oosaki R, Kashii T, Kawasashi A, Fujishita T, Arai N, Yamashita N, Maruyama M, Kobayashi M. [Long-term prognosis of asthmatic patients treated with low-dose beclomethasone dipropionate] Arerugi 49: 391-396, 2000.

Matsui S, Yamashita N, Narukawa M, Hayashi R, Yoshida Y, Arai N, Maruyama M, Kobayashi M, Kitagawa M, [Rheumatoid arthritis-associated bronchiolitis successfully treated with erythromycin] Nihon Kokyuki Gakkai Zasshi 38: 195-200, 2000.

Matsui S, Yamashita N, Nino T, Haki H, Sugiyama E, Maruyama M, Kobayashi M. Role of the endogenous prostaglandin E2 in human lung fibroblast interleukin-11 production. Respir Med 93: 637-642, 1999.

Yoshida Y, Kato B, Mizushima Y, Arai N, Matsui S, Maruyama M, Kobayashi M. Syndrome of inappropriate secretion of antidiuretic hormone associated with amyotrophic lateral sclerosis in respiratory failure. Respirology 4: 185-187, 1999.

Yoshida Y, Maruyama M, Fujita T, Arai N, Hayashi R, Araya J, Matsui S, Yamashita N, Sugiyama E, Kobayashi. Reactive oxygen intermediates stimulate interleukin-6 production in human bronchial epithelial cells. Am J Physiol 276: L900-L908, 1999.

Ohta T, Yamashita N, Maruyama M, Sugiyama E, Kobayashi M. Cigarette smoking decreases interleukin-8 secretion by human alveolar macrophages. Respir Med 92: 922-927, 1998.

Hayashi R, Yamashita N, Matsui S, Maruyama M, Sugiyama E, Sugiyama S, Kobayashi M. Bradykinin stimulates interleukin-8 production by human lung fibroblasts. Immunology 95: 507-511, 1998.

Maruyama M, Sugiyama E, Hori T, Murayama R, Nakazaki S, Yamashita N, Kobayashi M. Increased serum concentrations of secretory leukoprotease inhibitor in patients with primary Sjogren's syndrome. In Vivo 12: 535-538, 1998.

Takagawa J, Maruyama M, Yoshida Y, Arai N, Matsui S, Yamashita N, Sugiyama E, Kobayashi M. [Chronic necrotizing pulmonary aspergillosis resistant to antimycotic drugs and treated by partial pulmonary resection] Nihon Kokyuki Gakkai Zasshi 36: 519-523, 1998.

Yoshida Y, Niiya K, Maruyama M, Oosaki R, Fujishita T, Kobayashi M, Sakuragawa N. Efficacy of antithrombin concentrates in treatment for asthma symptoms complicated in antithrombin abnormality with no heparin binding activity. Clin Appl Thromb/Hemost 3: 288-289, 1997.

Yoshida Y, Harada S, Arai N, Matsui S, Maruyama M, Kobayashi M. [A case of pulmonary arteriovenous fistula presenting as multiple brain abscesses after a sustained period without treatment] Nihon Kokyuki Gakkai Zasshi 35: 1104-1107, 1997.

Sugiyama E, Kuroda A, Taki H, Ikemoto M, Hori T, Yamashita N, Maruyama M, Kobayashi M. Interleukin 10 cooperates with interleukin 4 to suppress inflammatory cytokine production by freshly prepared adherent rheumatoid synovial cells. J Rheumatol 22: 2020-2026, 1995.

Maruyama M, Hay JG, Yoshimura K, Chu CS, Crystal RG. Modulation of secretory leukoprotease inhibitor gene expression in human bronchial epithelial cells by phorbol ester. J Clin Invest 94: 368-375, 1994.

Yokoyama A, Maruyama M, Ito M, Kohno N, Hiwada K, Yano S. Interleukin 6 acitivity in pleural effusion: its diagnostic value and thrombopoietic activity. Chest 102: 1055-1059, 1992.

Chen MF, Suzuki H, Maruyama M, Yano S. The influence of FK-506 on the thymus and spleen in normal C3H/He mice: flow cytometric analysis of lymphocyte subpopulations. Immunol Lett 29: 255-259, 1991.

Yamashita N, Maruyama M, Yamazaki K, Hamazaki T, Yano S. Effect of eicosapentaenoic and docosahexaenoic acid on natural killer cell activity in human peripheral blood lymphocytes. Clin Immunol Immunopathol 59: 335-345, 1991.

Suzuki H, Ikemoto M, Yokoyama A, Kamitani T, Yamashita N, Maruyama M, Yano S. Interleukin-2-activated murine cell lines with macrophage- and B-lymphoblast-lytic activity. Cell Immunol 132: 127-139, 1991.

Maruyama M, Suzuki H, Yamashita N, Yano S. Effect of FK506 treatment on allocytolytic T lymphocyte induction in vivo: differential effects of FK506 on L3T4+ and Ly2+ cells. Transplantation 50: 272-277, 1990.

Maruyama M, Kawasaki A, Suzuki H, Yamashita N, Yano S. Lysis of human alveolar macrophages by lymphokine-activated killer cells. Chest 97: 1372-1376, 1990.

Mizushima Y, Hirata H, Izumi S, Hoshino K, Konishi K, Morinaga T, Maruyama M, Yamashita N, Yano S. Clinical significance of the number of positive tumor markers in assisting the diagnosis of lung cancer with multiple tumor marker assay. Oncology 47: 43-48, 1990.

Suzuki H, Yamashita N, Maruyama M, Yoshikawa T, Yano S. Human lymphokine-activated killer cells suppress pokeweed mitogen-induced immunoglobulin synthesis. Clin Exp Immunol 78: 406-411, 1989.

Sugiyama E, Iwata M, Yamashita M, Yoshikawa T, Maruyama M, Yano S. Immunosuppression by captopril in vitro: inhibition of human natural killer activity by copper-dependent generation of hyrogen peroxide. Jap J Med 25: 149-154, 1986.

Suzuki H, Yamashita N, Sato M, Maruyama M, Yano S. Natural killer-like activity in human cultured lymphoid cells propagated in the presence of interleukin-2: acquired resistance to prostaglandinE2 or dexamethasone-mediated suppression. Experientia 41: 667-669, 1985.

Yamashita N, Sugiyama E, Maruyama M, Mizushima Y, Yano S. Immunological studies of chest disease: (II) Effect of IL-2 and PGE2 on induction of nonspecific killer cells by lectin in lung concer patients. Jap J Med 24: 380, 1985.

Ito M, Suzuki H, Yamashita N, Sugiyama E, Maruyama M, Sato M, Iwata M, Yano S. Beneficial effect of interleukin-2 on natural killer activity in lung cancer patients. Anticancer Res 4: 375-376, 1984.

Yamashita N, Suzuki H, Maruyama M, Sugiyama E, Yano S. Effects of aging on the in vitro response of human lymphocytes to interleukin-2. Jap J Med. 23: 211-215, 1984.

Ito M, Sugiyama E, Yamashita N, Maruyama M, Yano S. Effects of interleukin-2 on cell growth and cytotoxicity fo lymphocytes in lung cancer. Jap J Med 22: 303, 1983.

Ito M, Suzuki H, Nakano N, Yamashita N, Sugiyama E, Maruyama M, Hoshino K, Yano S. Superoxide anion and hydrogen peroxide release by macrophages from mice treated with Nocardia rubra cell-wall skeleton: inhibition of macrophage cytotoxicity by a protease inhibitor but not by superoxide dismutase and catalase. Gann 74: 128-136, 1983.

Sugiyama E, Ito M, Suzuki H, Yamashita N, Maruyama M, Yano S. Natural killer cell activity associated with aging and sex in humans. Jap J Med 22: 195-199, 1982.

Ito M, Suzuki H, Nakano N, Yamashita N, Sugimori M, Sugiyama E, Maruyama M, Asanuma Y, Yano S. Effect of Nocardia rubra cell-wall skeleton on colony-stimulating activity and myeloid colony formation. Gann 73: 403-407, 1982.

富山県富山市荒川の内科、アレルギー科、呼吸器科の新庄内科クリニック